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apalutamide will lower the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication which can be CYP3A4 substrates can lead to reduced publicity to these medications.Belzutifan can be a CYP2C19 substrate. Coad